Only remake I can think of is FF7.
As for sequels:
Shadow of the Colossus
Megaman Legends (SERIOUSLY WTF WHY HASN'T THIS HAPPENED???)
Streets of Rage
All of the old school adventure games(Crash Bandicoot, Banjo-Kazooie, Spyro, etc)
Personally I wouldn't care but a new Killer Instinct would sell like crazy.
In these days of remakes and sequels where are the good ones??