There was a thread on emulation, but I can't seem to find it now. It had information about building it into arcade cabinets too.
Dolphin experience - it's mostly CPU based and doesn't take advantage of GPU power much, so it can require some horsepower to run things.
I think The Last Story is probably the hardest to run and you're not going to be able to run it at decent settings on anything less than a I5-2500k overclocked to at least 4.4ghz. Part of the problem with TLS is the the EFB Copy setting needs to be switched to RAM and the Texture Cache accuracy needs to be turned down a notch from the fastest setting towards the safe side or you constantly get missing textures and that slows speed down a bit.
Xenoblade's a lot easier to run now (you had to have some hacked audio stuff to get it to work right at first), but still requires some power.
Those are about the only games worth playing on it too, unless you go and buy a Wiimotion Plus controller/addon for Skyward Sword.